Isoflavonoids from Ficus benjamina and Their Inhibitory Activity on BACE1

Jingqiu Dai; Dai Shen; Wesley Y. Yoshida; Stephen M. Parrish; Philip G. Williams

doi:10.1055/s-0032-1315001

Planta Medica, Table of Contents

Planta Med 2012; 78(12): 1357-1362
DOI: 10.1055/s-0032-1315001

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Isoflavonoids from Ficus benjamina and Their Inhibitory Activity on BACE1

Jingqiu Dai

¹Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii, USA

,

Dai Shen

²Kenyon College, Gambier, Ohio, USA

,

Wesley Y. Yoshida

¹Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii, USA

,

Stephen M. Parrish

¹Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii, USA

,

Philip G. Williams

¹Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii, USA

³University of Hawaii Cancer Center, Honolulu, Hawaii, USA

› Author Affiliations

Abstract

Examination of an active extract of the fruit of Ficus benjamina var. nuda (Miq.) Barrett has led to the isolation of six new isoflavones and two coumarano-chroman-4-ones, along with fifteen known compounds. The structures of the eight new compounds were elucidated on the basis of extensive NMR experiments and mass spectrometric measurements. The inhibitory activity of the compounds on the proteolytic cleavage of amyloid precursor protein by the aspartic protease BACE1 was evaluated. Both coumarano-chroma-4-ones and some isoflavones showed moderate activity in this assay.

Key words

Ficus benjamina - Moraceae - isoflavonoid - BACE1

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References

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